Immediately after takeoff from Sigonella NAS on the Italian island of Sicily, the aircraft’s no. 3 engine experienced an uncontained failure. Debris was ejected and the caused no. 4 engine to also fail. Debris also severed the elevator trim electrical cables, eliminating any trim during flap retraction. Further debris entered the cargo compartment, starting a fire in a pallet containing paint. The cargo fire produced thick poisonous smoke which made visual control of aircraft extremely difficult. The aircraft entered a steep bank and crashed within 198 seconds of takeoff. Post crash toxicology indicated the crew had received potentially fatal levels of cyanide poisoning from the smoke, prior to impact. Subsequent to this accident, smoke goggles were added to crew oxygen masks. The aircraft operated on a service to Diego Garcia with a planned refueling and crew change stop at Nairobi, Kenya.