An Aer Caribe Boeing 737-400 cargo plane suffered a runway excursion after landing at Leticia Airport, Colombia. The aircraft took off from the Bogot  Airport at 15:50 hours local time. The flight was normal and the aircraft was cleared for the VOR approach to runway 21. The controller notified the crew of a 350ø wind at 4 knots and a wet runway. At 16:57, the aircraft touched down abeam taxiway Alpha. Immediately afterwards, when the deceleration began, with the application of the reverses, an explosion occurred. The crew observed that the auto-braking system was not operating, so they decided to deactivate it and execute manual braking. Both captain and first officer failed to get a response when applying the brakes so the captain decided to activate the reversers again with 400 metres of runway remaining. The aircraft continued to roll and crossed the threshold stopping in the safety zone, twenty meters from the runway threshold. Approximately one minute after the plane stopped, the crew opened the cargo door and evacuated by their own means; the four occupants were unharmed. Probable cause(s) The investigation determined that the accident was caused by the following causal factors: Poor maintenance procedures of the aircraft operator, by not applying complete and adequate corrective actions to determine the root cause of repeated tire failure. Brake system failure as a result of a break in the hydraulic lines and harness housed in the right landing gear compartment caused by pieces of rubber from tire No. 4 bursting during the landing run. Bursting of tire No. 4 due to the over bending action it suffered as a result of being inflated and over inflated repeatedly, due to different reports of low tire pressure. Runway departure during the deceleration during the landing manoeuvre in Leticia. Contributing Factors Inadequate risk management of the Operator, since the repeated reports of discrepancies were not known or dealt with by its Operational Safety Management area. Poor conditions in the safety zone, in the extension of the Leticia aerodrome’s header 03, whose unevenness and flooding contributed to the damage to the aircraft.